When an individual is diagnosed with breast cancer, it can either be caused by genes that have misfired sometime in your life, leading to the disease, or the cause is hereditary. This means that the breast cancer was caused by a mutation in a gene that has been passed down from a parent. While there are many gene mutations that may lead to breast cancer, BRCA 1 and BRCA 2 are the most common genes that are associated with hereditary breast cancer.
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BRCA 1 and BRCA 2
Both BRCA 1 and BRCA 2 are genes that create proteins that help to repair damaged DNA. Every individual has two copies of each of these genes, with one copy inherited from each parent. BRCA 1 and BRCA 2 are also known as tumor suppressor genes because when they have certain mutations, cancer can develop. Individuals who inherit harmful variants in one of these genes have an increased risk of different cancers, particularly breast and ovarian cancer. These individuals also tend to develop cancer at younger ages than those without the variants.
There is BRCA 1 and BRCA 2 mutation testing available, which can help to detect these genes in yourself and family members. For those who test positive for BRCA 1 or BRCA 2, there are several steps that can be taken to reduce cancer risk. These include enhanced screening, risk-reducing surgery (prophylactic surgery), and chemoprevention.
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What is Prophylactic Surgery?
Prophylactic surgery involves the removal of as much “at-risk” breast tissue as possible. Individuals may choose to have one or both breasts removed to reduce their risk of developing breast cancer. Women may also choose to have surgery to remove their ovaries and fallopian tubes to help reduce the risk of ovarian cancer. It is important to understand that these surgeries cannot be reversed, and should be considered thoroughly before making a final decision. While this surgery can reduce the risk of developing breast and/or ovarian cancer, it does not guarantee that you will not develop it, since it is impossible to remove all at-risk tissue. However, for women with the BRCA 1 or BRCA 2 gene mutation, prophylactic mastectomy can reduce the risk of developing breast cancer by 90-95%. Following prophylactic surgery, patients can then go on to undergo breast reconstruction surgery if desired.
Deciding on whether prophylactic surgery is right for you is best done alongside a trained and trustworthy plastic surgeon. The decision should not be urgent, and you should give yourself the time you need to weigh all of the pros and cons that are associated with the procedure.
Dr. Silvia Kurtovic is the most wonderful surgeon I could ever have asked for. I had breast cancer and two reconstruction surgeries following the original mastectomy. I was never happy with the results of either surgery. I came to see Dr. Kurtovic and was ever so pleased with the way she showed she truly cared and her professionalism was outstanding. she really listened to what I wanted with consideration of my emotions regarding my breast cancer and previous surgeries. Dr. Kurtovic did another reconstruction surgery of my breasts just two months ago and I could not be more thrilled with the results. She is an amazing talented and compassionate doctor that I would recommend highly.”
If you would like to learn more regarding reconstruction for gene mutations, contact Tucson Plastic Surgery today! We will be happy to schedule your consultation appointment, during which you can discuss your goals and concerns with one of our plastic surgeons.